Alkynes o lo'o i ai lautele i oloa fa'anatura, mole mole ola olaola ma mea fa'aola.I le taimi lava e tasi, e taua foi i latou i le faʻaogaina o meaola ma e mafai ona oʻo i le tele o suiga o vailaʻau.O le mea lea, o le atinaʻeina o auala faigofie ma lelei fau alkynes e faʻanatinati ma manaʻomia.E ui lava o le Sonogashira reaction catalyzed by transition metals o se tasi lea o auala e sili ona aoga ma faigofie e synthesize aryl po o alkenyl substituted alkynes, o le faʻaogaina o le faʻaogaina e aofia ai le alkyl electrophiles e le faʻaaogaina e mafua mai i itu e pei o le bH elimination.O lo'o tumu pea i lu'itau ma fa'aitiitia su'esu'ega, fa'atapula'a i alkanes fa'alesiosiomaga ma le taugata.O le mea lea, o le suʻesuʻeina ma le atinaʻeina o le Sonogashira tali o mea fou, taugofie ma faigofie ona maua alkylation reagents o le a taua tele i totonu ole suʻesuʻega suʻesuʻe ma faʻaoga pisinisi.O le 'au na mamanuina ma le atamai ma atiae se fou, faigofie ona maua ma mautu amide-ituaiga NN2 pincer ligand, lea mo le taimi muamua na iloa ai le lelei ma le maualuga o le filifilia o alkylamine derivatives ma alkynes terminal ma le tele o punaoa catalytic nickel, taugofie ma faigofie e. maua.O le tali fa'akoluse fa'atasi ua fa'aaogaina ma le manuia i le tuai deamination ma alkynylation suiga o oloa fa'anatura lavelave ma molela'au vaila'au, lea e fa'amaonia ai le lelei fa'atinoga fa'atinoga ma fa'atinoga vaega fa'atino, ma maua ai mea fou mo le tu'ufa'atasiga o alkyl-sui taua alkynes.Ma auala aoga.
Taimi meli: Nov-22-2021